Projects
MAMELI
Mapping the Methylation of repetitive elements to track the Exposome effects on health: the city of Legnano as a Living lab
Ente finanziatore: European Research Council (ERC) Consolidator Grant
The main objective of MAMELI is to study the epigenetic mechanisms (those modifications in the expression of our genes that do not involve an alteration ofoccur without altering the composition sequence of our DNA) that mediate the effect of the exposome on health. The exposome represents the set totality of all factors – internal and external – that influence human health throughout life. The link between exposome and health is supported by evidence: the development of a state of illness is largely determined by behavioral, environmental, and occupational risk factors, many of which are, at least potentially, modifiable.
Principal Investigator: Valentina Bollati
HEBE
Healthy aging versus inflamm-aging: the role of physical Exercise in modulating the Biomarkers of age-associated and Environmentally determined chronic diseases.
Funding Body: GSA – Grandi Sfide di Ateneo, University of Milan.
HEBE is a cross-sectional and multidisciplinary project involving 140 researchers from the University of Milan (UNIMI), belonging to 40 Scientific-Disciplinary Sectors and organized into 13 departmental units and 10 research lines.
Principal Investigators: Mario Clerici, Elia Biganzoli
Core Executive Team: Valentina Bollati, Francesca Bianchi, Chiara Mando’, Daniela Lucini
Project Manager: Federica Rota
INSIDE – OUT
Breast milk extracellular vesicles: maternal resilience to counterbalance life-threatening infant’s conditions.
Funding Body: Italian Ministry of Health (“Ricerca Finalizzata”)
Principal Investigators: Gregorio Milani, Valentina Bollati, Massimiliano Buoli, Anna Pistocchi
This Project was funded by the Italian Ministry of Health.
BUG
Nasal microbiota, bronchiolitis and air pollution: the Good, the Bad and the Ugly.
Funding Body: PRIN – PROGETTI DI RICERCA DI RILEVANTE INTERESSE NAZIONALE, Call 2017
Principal Investigators: Valentina Bollati, Gregorio Milani, Anna Pistocchi, Eva Pinatel, Anna Luganini, Luigi Pariota.
This Project was funded by the Italian Ministry of Education, University and Research under grant agreement number 2017HWPZZZ.
DeprAIR
Depression is in the air: understanding the interplay between air pollution, biological variables and depressive disorder.
Funding Body: Cariplo Foundation Principal Investigators: Michele Carugno, Valentina Bollati, Massimiliano Buoli.
Main Completed Projects
SPHERE
SPHERE: Susceptibility to Particle Health Effects, miRNAs and Exosomes
Funding Body: European Research Council (ERC) Starting Grant.
Principal Investigator: Valentina Bollati.
This project received funding from the European Union’s Seventh Framework Programme for research, technological development, and demonstration under grant agreement number 282413.
INSIDE
INdividual air pollution exposure, extracellular vesicle SIgnaling and hypertensive disorder DEvelopment in pregnancy.
Funding Body: PRIN – PROGETTI DI RICERCA DI RILEVANTE INTERESSE NAZIONALE, Call 2015
Principal Investigator: Valentina Bollati.
This Project was funded by the Italian Ministry of Education, University and Research under grant agreement number 20152T74ZL.
EPIMIGRANT
EpiMigrant: Identification of epigenetic markers underlying increased risk of Type 2 diabetes in South Asians.
Funding Body: Specific International Cooperation Action (SICA), Collaborative Project.
Programme Themes: HEALTH.2011.2.4.3-4 Genetic and environmental factors in obesity and/or diabetes in specific populations.
Principal Investigator: Dr John Chambers, Imperial College London.
This project received funding from the European Union’s Seventh Framework Programme for research, technological development, and demonstration under grant agreement number 279143.
MFAG
Germline epimutations in malignant melanoma
Funding Body: My First Airc Grant AIRC
Principal Investigator: Valentina Bollati.
This project received funding from the Italian Association for Cancer Research (AIRC) under grant agreement number 10361.